Potential diseases

One of the diseases I am interested in is amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. It is characterized by progressive loss of muscle function and physical control of one’s body. Th cause is unknown and there is currently no cure. Throat cancer is a variety of cancer that affects the throat and larynx, and one of the major risk factors is smoking. Throat cancer survivors can have difficulties with eating and speaking as a result of both cancer and treatment. Polio is a devastating disease that often cripples its victims. Once widely spread, it has become almost nonexistent due to the development of a vaccine and the strong efforts to implement it. However, polio and many other diseases with vaccinations may see a resurgence due to what the World Health Organization calls “vaccine hesitancy” and has listed as one of its ten threats to global health in 2019 (https://www.who.int/emergencies/ten-threats-to-global-health-in-2019).

One Reply to “Potential diseases”

  1. Hi Evan – ALS can work if you focus in a bit. https://www.omim.org/entry/105400 – this entry in OMIM is for ALS1 that makes up 15-20% of cases, there are MANY versions of ALS, and I agree, the cause isn’t always known. The trick will be to pick a type of ALS on which research is still happening. Polio can work, but the disease is very old, and it was eradicated over 50 years ago…I’m not sure how much recent work there is.

    Throat cancer is pretty broad. Focusing on a specific mutation that drives a cancer type is the best way to go. Since smoking is a risk factor, the mutations are going to likely be somatic and spontaneous, but PD-1 checkpoint inhibitors have been recently successful against cancers caused by environmental factors. Try this paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894505/ – you’ll need to focus in.

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